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Zi-Jie Long Selected Research

tozasertib

11/2013Inhibition of mTOR pathway sensitizes acute myeloid leukemia cells to aurora inhibitors by suppression of glycolytic metabolism.
5/2011Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells.
11/2009Aurora-A down-regulates IkappaBalpha via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival.
8/2009Inhibition of Aurora-A results in increased cell death in 3-dimensional culture microenvironment, reduced migration and is associated with enhanced radiosensitivity in human nasopharyngeal carcinoma.

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Zi-Jie Long Research Topics

Disease

18Neoplasms (Cancer)
01/2022 - 05/2008
7Leukemia
11/2020 - 01/2016
5Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
11/2020 - 05/2011
4Breast Neoplasms (Breast Cancer)
05/2022 - 08/2014
4Nasopharyngeal Carcinoma
01/2020 - 08/2009
4BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
11/2016 - 03/2014
3Polyploidy
11/2016 - 11/2013
3Acute Promyelocytic Leukemia
01/2014 - 05/2011
2Carcinogenesis
01/2022 - 10/2008
2Epilepsy (Aura)
11/2016 - 08/2014
2Necrosis
01/2016 - 03/2012
2Carcinoma (Carcinomatosis)
08/2009 - 05/2008
1Bites and Stings (Sting)
01/2022
1Disease Progression
09/2020
1Anaplastic Thyroid Carcinoma
08/2018
1Endocrine Gland Neoplasms (Cancer, Endocrine)
08/2018
1Thyroid Neoplasms (Thyroid Cancer)
08/2018
1Liver Neoplasms (Liver Cancer)
03/2017
1Hepatocellular Carcinoma (Hepatoma)
03/2017
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
08/2015
1Tics (Tic)
08/2014
1Fever (Fevers)
03/2014
1Neoplasm Metastasis (Metastasis)
04/2010
1Aneuploidy (Aneuploid)
05/2008

Drug/Important Bio-Agent (IBA)

7Aurora Kinase AIBA
11/2020 - 08/2009
5Aurora KinasesIBA
05/2022 - 05/2008
4tozasertibIBA
11/2013 - 08/2009
3RetinoidsIBA
01/2020 - 05/2011
3Imatinib Mesylate (Gleevec)FDA Link
11/2016 - 01/2015
3AKI603IBA
11/2016 - 08/2014
2Annexin A5IBA
01/2016 - 03/2012
2Cadherins (E-Cadherin)IBA
03/2015 - 10/2008
2Sirolimus (Rapamycin)FDA Link
09/2014 - 11/2013
2Phosphotransferases (Kinase)IBA
08/2014 - 10/2008
24- (4- (N- benzoylamino)anilino)- 6- methoxy- 7- (3- (1- morpholino)propoxy)quinazolineIBA
11/2013 - 05/2008
2AcidsIBA
02/2012 - 05/2011
2Caspase 3 (Caspase-3)IBA
08/2009 - 05/2008
1InterferonsIBA
01/2022
1DNA (Deoxyribonucleic Acid)IBA
01/2022
1cyclic guanosine monophosphate-adenosine monophosphateIBA
01/2022
1STAT5 Transcription FactorIBA
11/2020
1CytokinesIBA
09/2020
1InterleukinsIBA
09/2020
1Interleukin-6 (Interleukin 6)IBA
09/2020
1Biological ProductsIBA
01/2019
1MicroRNAs (MicroRNA)IBA
01/2019
1Competitive Endogenous RNAIBA
01/2019
1Long Noncoding RNAIBA
01/2019
1Messenger RNA (mRNA)IBA
01/2019
1Antipsychotic Agents (Antipsychotics)IBA
03/2017
1Pharmaceutical PreparationsIBA
03/2017
1Pimozide (Orap)FDA Link
03/2017
1PyrimidinesIBA
11/2016
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
01/2016
1bisbenzimide ethoxide trihydrochloride (Hoechst 33342)IBA
01/2016
1Celecoxib (Celebrex)FDA Link
01/2016
1Transcription Factors (Transcription Factor)IBA
08/2015
1AnthelminticsIBA
03/2015
1Fluorouracil (Carac)FDA LinkGeneric
03/2015
1flubendazoleIBA
03/2015
1Doxorubicin (Adriamycin)FDA LinkGeneric
03/2015
1Keratin-18 (Keratin 18)IBA
03/2015
1VimentinIBA
03/2015
1CateninsIBA
03/2015
1Differentiation AntigensIBA
03/2015
1Epirubicin (Ellence)FDA LinkGeneric
08/2014
1mangostinIBA
03/2014
1Transaminases (Aminotransferases)IBA
03/2014
1AnthracyclinesIBA
01/2014
1Tretinoin (Retinoic Acid)FDA LinkGeneric
01/2014
1Arsenic Trioxide (Trisenox)FDA Link
01/2014
1MTOR InhibitorsIBA
11/2013
1Glucose (Dextrose)FDA LinkGeneric
11/2013
1Lactic Acid (Lactate)FDA LinkGeneric
11/2013
1PP242IBA
11/2013
1Deoxyglucose (2 Deoxy D glucose)IBA
11/2013
1Bisbenzimidazole (Hoechst 33258)IBA
03/2012
1theasinensin AIBA
03/2012
1DecitabineFDA Link
02/2012
1Daunorubicin (Cerubidine)FDA LinkGeneric
05/2011
1CurcuminIBA
05/2011
1Neutralizing AntibodiesIBA
12/2010
1Deoxyribonucleases (DNase)FDA Link
12/2010
1Beclin-1IBA
04/2010
1NF-kappa B (NF-kB)IBA
11/2009
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
11/2009
1NF-KappaB Inhibitor alphaIBA
11/2009
1Insulin (Novolin)FDA Link
11/2009
1beta CateninIBA
10/2008
1Histones (Histone)IBA
05/2008

Therapy/Procedure

7Therapeutics
01/2022 - 03/2012
6Drug Therapy (Chemotherapy)
11/2020 - 11/2009
1Immunotherapy
01/2022
1Radiotherapy
08/2018
1Intraperitoneal Injections
03/2015